Майкл Стюарт Браун: біографія

Біографія

Майкл Браун закінчив Університет Пенсільванії в 1962 і медичну школу цього ж університету в 1966. З тих пір працює в Південно-Західному медичному центрі (Університет Техасу) в області метаболізму холестерину. Автор багатьох статей у провідних світових біологічних і медичних журналах. У 1985 році отримав Нобелівську премію за відкриття рецептора ліпопротеїнів низької щільності.

Бібліографія

Основні наукові публікації:

Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man. Science. 1974 Jul 5; 185 (4145) :61-3.

Regulation of the activity of the low density lipoprotein receptor in human fibroblasts. Cell. 1975 Nov; 6 (3) :307-16.

Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans. Cell. 1976 Jan; 7 (1) :85-95.

Receptor-mediated control of cholesterol metabolism. Science. 1976 Jan 16; 191 (4223) :150-4.

Heterozygous familial hypercholesterolemia: failure of normal allele to compensate for mutant allele at a regulated genetic locus. Cell. 1976 Oct; 9 (2) :195-203.

Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein. Cell. 1976 Dec; 9 (4 PT 2) :663-74.

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts. Cell. 1977 Mar; 10 (3) :351-64.

Genetics of the LDL receptor: evidence that the mutations affecting binding and internalization are allelic. Cell. 1977 Nov; 12 (3) :629-41.

A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts. Nature. 1977 Dec 22-29; 270 (5639) :695-9.

Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: relation to low density lipoprotein receptor distribution. Cell. 1978 Nov; 15 (3) :919-33.

Coated pits, coated vesicles, and receptor-mediated endocytosis. Nature. 1979 Jun 21; 279 (5715) :679-85

LDL receptors in coated vesicles isolated from bovine adrenal cortex: binding sites unmasked by detergent treatment. Cell. 1980 Jul; 20 (3) :829-37.

Regulation of plasma cholesterol by lipoprotein receptors. Science. Тисячу дев'ятсот вісімдесят один May 8; 212 (4495) :628-35.

Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts. Cell. Тисячу дев'ятсот вісімдесят один May; 24 (2) :493-502.

Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia. Cell. 1982 Oct; 30 (3) :715-24

Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages. Science. 1983 Feb 18; 219 (4586) :871-3.

Recycling receptors: the round-trip itinerary of migrant membrane proteins. Cell. 1983 Mar; 32 (3) :663-7

The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor. Cell. 1983 Mar; 32 (3) :941-51.

Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts. Cell. 1983 May; 33 (1) :273-85

Increase in membrane cholesterol: a possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells. Cell. 1984 Apr; 36 (4) :835-45.

Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum. Nature. 1984 Apr 12-18; 308 (5960) :613-7.

Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor. Cell. 1984 Jun; 37 (2) :577-85.

HMG CoA reductase: a negatively regulated gene with unusual promoter and 5 'untranslated regions. Cell. 1984 Aug; 38 (1) :275-85.

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 1984 Nov; 39 (1) :27-38

Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. Science. 1985 Jan 11; 227 (4683) :140-6.

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